Media Contact

Adam Daley
Berry & Company Public Relations
adaley@berrypr.com
212-253-8881

Press Releases

November 14, 2022
Sionna Therapeutics Announces Appointment of Vanya Sagar as Chief People Officer
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November 3, 2022
Sionna Therapeutics Presents Preclinical Data Demonstrating Restoration of ΔF508-CFTR by Stabilizing NBD1 with SION-638 in Cystic Fibrosis
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October 4, 2022
Sionna Therapeutics to Present at the North American Cystic Fibrosis Conference
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August 1, 2022
Sionna Therapeutics Announces Formation of Scientific Advisory Board
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June 6, 2022
Sionna Therapeutics Announces Appointment of Paul Clancy to Board of Directors
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April 19, 2022
Sionna Therapeutics Launches with $111 Million Series B Financing to Advance Pipeline of Novel Small Molecules with the Potential to Fully Restore CFTR Function in Cystic Fibrosis
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Our Presentations

Stifel Healthcare Conference   |   November 15, 2022
Corporate presentation
Stifel Healthcare Conference   |   November 15, 2022
Webcast Link
NACFC   |   November 4, 2022
Oral Presentation – Novel Modulator Combinations Address the NBD1 Stability Defect Central to ΔF508-CFTR Dysfunction and Enable Full Correction
NACFC   |   November 3, 2022
Poster – Novel Modulator Combinations Address the NBD1 Stability Defect Central to ΔF508-CFTR Dysfunction and Enable Full Correction

Supporting Scientific Literature

Nature Chemical Biology   |   August 2, 2021
A topological switch in CFTR modulates channel activity and sensitivity to unfolding
Journal of Cystic Fibrosis   |   January 3, 2020
Towards next generation therapies for cystic fibrosis: Folding, function and pharmacology of CFTR
Journal of Molecular Biology   |   January 16, 2015
Restoration of NBD1 thermal stability is necessary and sufficient to correct ∆F508 CFTR folding and assembly
Journal of Cystic Fibrosis   |   March 14, 2014
Sweat chloride as a biomarker of CFTR activity: Proof of concept and ivacaftor clinical trial data
Nature Chemical Biology   |   May 12, 2013
Mechanism-based corrector combination restores ΔF508-CFTR folding and function
Cell   |   January 20, 2012
Correction of both NBD1 energetics and domain interface is required to restore ΔF508 CFTR folding and function
PLOS ONE   |   November 30, 2010
The primary folding defect and rescue of ΔF508 CFTR emerge during translation of the mutant domain